Dr. Rakesh Srivastava

DR. RAKESH K. SRIVASTAVA

Diabetes

A COMPREHENSIVE GUIDE ON DIABETES, CAUSES, SYMPTOMS AND TREATMENTS

Diabetes Diabetes is an enduring disease that influences how your body regulates blood sugar. It can cause serious health problems, including heart disease, stroke, and kidney failure. Causes of Diabetes   There are several different causes of it, and it is important to be aware of them if you or a loved one has the …

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Dr. Rakesh Srivastava

CAUSES AND EFFECTS PREVENTING OBESITY IN CHILDREN TEENS AND ADULTS

What Is Obesity? The word obesity has become synonymous with being fat and unhealthy. However, this is not the whole picture. it can measure excess body fat that puts you at risk for developing weight-related diseases like diabetes and hypertension. But being overweight or obese is not always bad for your health; it all depends …

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Association of Diabetes Mellitus and Alcohol Abuse with Cancer: Molecular Mechanisms and Clinical Significance

Abstract Diabetes mellitus (DM), one of the metabolic diseases which is characterized by sustained hyperglycemia, is a life-threatening disease. The global prevalence of DM is on the rise, mainly in low- and middle-income countries. Diabetes is a major cause of blindness, heart attacks, kidney failure, stroke, and lower limb amputation. Type 2 diabetes mellitus (T2DM) …

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hepatocellular carcinoma

Assessment of risk factors, and racial and ethnic differences in hepatocellular carcinoma

Abstract   Despite improved screening and surveillance guidelines, significant race/ethnicity-specific disparities in hepatocellular carcinoma (HCC) continue to exist and disproportionately affect minority and disadvantaged populations. This trend indicates that social determinants and genetic and environmental factors are driving the epidemic at the population level. Race and geography had independent associations with mortality risk among patients …

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cancer cell

Riluzole regulates pancreatic cancer cell metabolism by suppressing the Wnt-β-catenin pathway

Cancer Cell Abstract Most cancer cells rely on aerobic glycolysis to support uncontrolled proliferation and evade apoptosis. However, pancreatic cancer cells switch to glutamine metabolism to survive under hypoxic conditions. Activation of the Wnt/β-catenin pathway induces aerobic glycolysis by activating enzymes required for glucose metabolism and regulating the expression of glutamate transporter and glutamine synthetase. …

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Scholars

Volkin, Srivastava Named KU’s Second, Third Eminent Scholars

Kansas Bioscience Authority Commits $4.3 Million To Support Professors Scholars A prominent pharmaceutical scientist with 20 years of industrial research and development experience joined the KU faculty earlier this month, thanks partly to a five-year, $2.5 million financial commitment from the Kansas Bioscience Authority Scholars. David Volkin comes to KU from Centocor R&D, a subsidiary …

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angiogenesis

EGCG inhibits growth, invasion, angiogenesis and metastasis of pancreatic cancer

Sharmila Shankar1, Suthakar Ganapathy1, Sunil R. Hingorani2, Rakesh K. Srivastava1 1Department of Biochemistry, University of Texas Health Science Center at Tyler, Tyler, Texas, USA 75703, 2Clinical Research Division, Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle, WA 98109 TABLE OF CONTENTS1. Abstract2. Introduction3. Materials and Methods3.1. Reagents3.2. Cell culture and cell survival assay3.3. …

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OBESITY

The Impact of Obesity and Diabetes Mellitus on Pancreatic Cancer : Molecular Mechanisms and Clinical Perspectives

The Impact of Obesity and Diabetes Mellitus on Pancreatic Cancer : An expanding body of preclinical evidence suggests EGCG, the major catechin found in green tea (Camellia sinensis), has the potential to impact a variety of human diseases. Apparently, EGCG functions as a powerful antioxidant, preventing oxidative damage in healthy cells, but also as an …

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