OBESITY

The Impact of Obesity and Diabetes Mellitus on Pancreatic Cancer : Molecular Mechanisms and Clinical Perspectives

117 Comments / HealthCare / By

The Impact of Obesity and Diabetes Mellitus on Pancreatic Cancer :

An expanding body of preclinical evidence suggests EGCG, the major catechin found in green tea (Camellia sinensis), has the potential to impact a variety of human diseases. Apparently, EGCG functions as a powerful antioxidant, preventing oxidative damage in healthy cells, but also as an antiangiogenic and antitumor agent and as a modulator of tumor cell response to chemotherapy. Much of the cancer chemopreventive properties of green tea are mediated by EGCG that induces apoptosis and promote cell growth arrest by altering the expression of cell cycle regulatory proteins, activating killer caspases, obesity and suppressing oncogenic transcription factors and pluripotency maintain factors. In vitro studies have demonstrated that EGCG blocks carcinogenesis by affecting a wide array of signal transduction pathways including JAK/STAT, MAPK, PI3K/AKT, Wnt, and Notch. EGCG stimulates telomere fragmentation through inhibiting telomerase activity. Various clinical studies have revealed that treatment by EGCG

inhibits tumor incidence and multiplicity in different organ sites such as liver, stomach, skin, lung, mammary gland and colon. Recent work demonstrated that EGCG reduced DNMTs, proteases, and DHFR activities, which would affect transcription of TSGs and protein synthesis. EGCG has great potential in cancer prevention because of it’s safety, low cost and bioavailability. In this review, we discuss its cancer preventive properties and it’s mechanism of action at numerous points regulating cancer cell growth, survival, angiogenesis and metastasis. Therefore, non-toxic natural agent could be useful either alone or in combination with conventional therapeutics for the prevention of tumor progression and/or treatment of human malignancies.Impact of Obesity and Diabetes

Keywords: Chemoprevention, Cell cycle, Apoptosis, Cellular signaling cascades, EGCG Go to: Dr Rakesh Srivastava

117 thoughts on “The Impact of Obesity and Diabetes Mellitus on Pancreatic Cancer : Molecular Mechanisms and Clinical Perspectives”

  33. porn tube

    You are so interesting! I don’t thinmk I hve readd something like that before.
    So good tto find somebody wioth some original thougthts on this
    subkect matter. Really.. many hanks for staeting thuis up.
    This site is somjething thazt is reqauired on the internet, somwone with a bit of originality!

    Reply
  38. krakensymn

    The kraken onion shop is a beguiling and mysterious site that continues to please users from around the planet. With its tremendous variety of things and services, combined with its engagement to privacy and security, Кракен через тор остальные тут has strengthened its position as a backbone in the dark internet trading. Those who are confident enough to venture into this deep web territory will find a dimension of intrigue and fortune, but always bear in mind to use it with care when surfing the deep waters of the kraken onion site.

    Reply
  39. krakensymn

    The dark and volatile architecture of the dark network is place to a number of gripping marketplaces, and one that has been receiving major commitment newly is the kraken onion market. Famous by its exceptional and onion URL, ссылка тор кракен магазин , this magical site is an enthralling destination for dudes obsessed with exploring the grounds of the deep web. Offering a several range of items and services, the kraken onion market is beyond shadow of a doubt a intriguing harbor for anyone with a taste for the secret side of internet.

    Reply
  44. porn xnxx

    Attractive section of content. I juhst stumbled uponn your website annd inn accessikon capitgal too assert hat I get actually
    enjoyed account your bloig posts. Anyway I will be subscribing too youyr augmrnt and evrn I achievement you access consistently
    quickly.

    Reply
  52. sitemap

    Whats upp this is somerwhat oof offf topic but I wass wondering iff blogss usee WYSIWYG editors oor if youu have tto manually
    code with HTML. I’m starting a bllog soon buut hzve
    no codimg know-how soo I wanted too get advie frtom someone
    wiuth experience. Anny hedlp ould bee enormously appreciated!

    Reply
  53. sitemap.xml

    Hey I kknow thyis is off topic bbut I wwas wonfering iff yyou new of any widgets I cpuld add to my
    blog that automaticaly tweest my newwest taitter updates.
    I’ve been loooking forr a plug-in like tis forr qukte sime time annd was hopong maybe you would have somme experience withh something like this.
    Please llet mme know iif you run intfo anything. I
    truly ebjoy readinmg yopur blolg annd I look forward to your nnew updates.

    Reply
  54. BVZ_Moskva_s

    Быстро возводимые здания: прибыль для бизнеса в каждом кирпиче!
    В нынешней эпохе, где время – деньги, объекты быстрого возвода стали истинным спасением для компаний. Эти инновационные конструкции комбинируют в себе высокую надежность, экономичное использование ресурсов и мгновенную сборку, что дает им возможность отличным выбором для различных бизнес-проектов.
    Проект быстровозводимого здания цена
    1. Ускоренная установка: Секунды – определяющие финансовые ресурсы в деловой сфере, и экспресс-сооружения позволяют существенно сократить сроки строительства. Это чрезвычайно полезно в моменты, когда необходимо оперативно начать предпринимательскую деятельность и начать извлекать прибыль.
    2. Финансовая выгода: За счет оптимизации производства и установки элементов на месте, экономические затраты на моментальные строения часто бывает менее, по сравнению с традиционными строительными проектами. Это обеспечивает экономию средств и достичь большей доходности инвестиций.
    Подробнее на http://scholding.ru
    В заключение, скоро возводимые строения – это превосходное решение для бизнес-мероприятий. Они объединяют в себе быстроту монтажа, финансовую эффективность и надежные характеристики, что обуславливает их первоклассным вариантом для предприятий, ориентированных на оперативный бизнес-старт и обеспечивать доход. Не упустите возможность сократить затраты и время, наилучшие объекты быстрого возвода для вашего следующего проекта!

    Reply
  55. Jacques

    I am curious to find out what blog system you have been working with?
    I’m experiencing some small security problems with my latest site and I
    would like to find something more secure. Do you have any suggestions?

    Reply
  57. Sammy

    Hi there! I know this is somewhat off-topic but I needed to
    ask. Does running a well-established blog such as yours
    require a massive amount work? I am completely new to writing a blog however I do write in my diary
    every day. I’d like to start a blog so I can easily share my personal
    experience and thoughts online. Please let me know if
    you have any kind of ideas or tips for brand new aspiring bloggers.
    Appreciate it!

    Reply
  59. Josh

    Good day! I could have sworn I’ve been to this site before
    but after browsing through some of the post I realized it’s new to me.
    Anyhow, I’m definitely happy I found it and I’ll be book-marking and checking back frequently!

    Reply

Leave a Comment

Your email address will not be published. Required fields are marked *